Kidney health calculator3/19/2023 Age-related increases in tubular secretion result in overestimation of GFR. This leads to an underestimation of creatinine excretion. This is due to creatinine being freely filtered by the glomerulus while also being secreted by the capillaries.įurther challenges to measuring creatinine clearance involve improper urine collection. But despite the fact that CrCl calculations are performed commonly, GFR calculation is not error free. Healthcare professionals need the CrCl calculations in order to provide the estimated GFR – as GFR is not measured directly in practice. Serum creatinine samples are typically collected more than urine samples. For comparison purposes, serum collection has to be within 24 hours of urine collection and vice versa. Creatinine collected from one source can be compared with creatinine from the other source. Healthy kidneys filter it out, but if you have kidney disease, creatinine stays in the blood and gradually builds up.Ĭreatinine levels and GFR are both measured by using creatinine samples from serum or urine. The GFR reveals the rate at which fluid is filtered by the kidneys, while creatinine clearance, CrCl, measure how much creatinine is in your blood. Accurate calculation of GFR and CrCl are therefore vital to minimizing risks to patients. Pharmacists strive to avoid the risks associated with the progression of kidney disease, of overdosing or underdosing – indeed any factors that potentially hinder optimal delivery of treatments and the patient’s recovery. The calculation is complex, based on multiple factors like age, body size, sex, race/ethnicity, as well as the level of creatinine – a waste product – in the blood. Monitoring our GFR helps doctors keep an eye out for the onset of kidney disease – the major disease of concern being Chronic Kidney Disease (CDK) – and provide the right degree of individualized treatment, ranging from advice on simple lifestyle changes through to kidney transplant or dialysis. The GFR measures how much blood these filters can clean every minute. Glomeruli are tiny filters in our kidneys that help remove toxins from our blood. Healthcare professionals use a measurement known as the Glomerular Filtration Rate (GFR) to monitor how well our kidneys are working to clean our blood. Kidney health is key to our overall wellbeing.
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